B-RST™ Score Interpretation

POSITIVE: Person has a 5-10% or greater chance of carrying a mutation in BRCA1 or BRCA2, which are associated with substantially increased risks (10 fold or more) for early onset breast cancer and ovarian cancer. Referral for cancer genetic counseling is indicated.

Note: Individuals who screen positive on the B-RST™ may not be found to be appropriate candidates for BRCA1/2 testing when a comprehensive cancer risk assessment is performed.

NEGATIVE: Person is unlikely to carry a BRCA1/2 mutation.

LOW Risk = Based on family history, person's risks for breast/ovarian cancer expected to be at or below that of the general population.

MODERATE Risk = Persons who do not have a family history suggestive of hereditary cancer, but may have a risk for breast and/or ovarian cancer that is somewhat increased (~2-4 fold) above that of the general population. Further risk assessment and/or enhanced screening or prevention strategies may be appropriate for some of these individuals. ( Commun Oncol, 2009; 6:373)


  • This screening tool does not assess non-familial risk factors for breast or ovarian cancer.
  • Changes in family history could result in a change in the risk score. B-RST™ should be re-run if additional cases of breast and/or ovarian cancer occur.
  • In families with few females, single cases of ovarian cancer or early breast cancer may be related to a BRCA1/2 mutation.
  • There are other, less common hereditary causes of breast and ovarian cancer. A cancer genetics consultation should be pursued if:
    • There are multiple individuals with cancer in multiple generations
    • Cancers are of an usually early age of onset
    • Rare or unusual cancers or tumors have occurred (examples: cancer of adrenal glands, medullary thyroid cancer, hamartomatous polyps, paragangliomas)
B-RST™ Genetics Referral Screening Tool Copyright 2012 - 2019 Emory University, created by Cecelia Bellcross, PhD, MS, CGC
BreastCancerGeneScreen.org © Georgia Center for Oncology Research and Education
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